.ALPHA.,.ALPHA.-gem-Difluorination of .ALPHA.-(Alkylthio)acetophenone Derivatives with N-Fluoropyridinium Salts.
نویسندگان
چکیده
منابع مشابه
Preparation of imidazo[1,2-a]-N-heterocyclic derivatives with gem-difluorinated side chains
Using an aerobic oxidative coupling, different new imidazo[1,2-a]-N-heterocycles with gem-difluroroalkyl side chains have been prepared in fair yields by the reaction of gem-difluoroenones with aminopyridines, -pyrimidines and -pyridazines. Condensed heterocycles of this type play an important role as key core structures of various bioactive compounds. Further, starting with a chloroimidazopyri...
متن کاملSynthesis of New Pyrazole Derivatives Using Vinamidinium Salts
Novel pyrazole derivatives 2-7 are synthesized by the reaction of 2-substituted 1,3-bis(dimethylamino)-trimethinium salts with phenyl hydrazine in acetonitrile as the solvent. This method has some advantages of high yields (78-85%), simplicity of the process and easy of control. The ultraviolet spectral behavior of the synthesized compounds is examined in CDCl3 and their structures were charact...
متن کاملGEM Optimizing Compilers for Alpha AXP Systems
Digital’s GEM compiler technology is used to generate state-of-the-art compilers for a voriety of ianguages and hardware/software platforms. The Alpha A X P ( tm) architecture provides a number of opportunaties and challenges for compiler writers. This paper describes techniques used to optimize pipelining, multiple instruction issue, and memory references.
متن کاملFluorescent derivatives of bile salts. II. Suitability of NBD-amino derivatives of bile salts for the study of biological transport.
Interaction of unconjugated and taurine-conjugated NBD-amino-dihydroxy-5 beta-cholan-24-oic acids bearing the fluorophor in the 3 alpha, 3 beta, 7 alpha, 7 beta, 12 alpha, or 12 beta position with albumin results in a small hypsochromic shift of the emission maximum and an increase in quantum yield, suggesting binding by hydrophobic interactions. The different unconjugated fluorescent bile salt...
متن کاملDesign of symmetrical and nonsymmetrical N,N-dimethylaminopyridine derivatives as highly potent choline kinase alpha inhibitors.
Choline kinase alpha is hyperactivated in many solid tumours and regulates malignant progression, making it a promising cancer drug target. The successful design and synthesis of novel inhibitors with high cellular activity are described.
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Chemical and Pharmaceutical Bulletin
سال: 2000
ISSN: 0009-2363,1347-5223
DOI: 10.1248/cpb.48.1097